In a paper accepted today in J. Bacteriology, PhD candidate Tiffany Leighton, building on preliminary work by former trainees Neha Dayalani and Dr. Liliana Sampaleanu, showed that alignment subcomplex components PilNO modulate both pilus extension and pilus retraction. She found that mutating only a single residue in either protein at a critical site blocked motility while permitting pilus assembly, a hallmark of retraction defects. These unexpected findings add PilNO to the repertoire of proteins that control motility in Pseudomonas. Congratulations Tiffany and coauthors!
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